The circadian rhythm sleep disorders also called sleep-wake rhythm, characterized by an inability to sleep due to the mismatch between the brain pacemaker that controls circadian rhythm sleep of the person and the sleep-wake schedule required or be normal in the environment in which the person develops. They can occur with insomnia or hypersomnia and frequently associated with nonspecific dysphoric symptoms such as malaise and lack of energy.
The circadian rhythm of sleep and insomnia difference hypersomnia by history and by the fact that usually improves if the subject is allowed to follow their own sleep-wake rhythm.
Loa different circadian thymic disorders are:
1. Phase delay Sindromde
Two. Lag syndrome Time Zones (Jet Lag)
Three. Worker to turnso
April. Phase advance syndrome
May. Sleep-wake rhythm irregular
June. Hipernictameral Syndrome
PHASE SYNDROME SLEEP DELAY
The patient falls asleep and wakes up later than the desired time, in a period exceeding one month. It occurs mainly in adolescents and young adults, and 2 times more males than females. Many patients have chronic sleep deprivation due to the need to wake up in the morning to meet their social and labor obligations, and thus have daytime sleepiness. It can lead to a depressive syndrome. During holidays insomnia disappears because it can go its own sleep-wake rhythm without any problem. He complains of inability to fall asleep or wake up spontaneously at the desired time, or tiredness. Presents a delayed sleep phase with respect to principal desired sleep time. These symptoms must be present for at least 1 month.
When not require any strict sleep pattern (eg., On holiday), the patient:
1. It has a habitual sleep period that is deep and lasting quality and standard.
Two. He wakes up spontaneously.
Three. Maintains a stable pattern of sleep-wake 24 h, although with a lag phase.
April. Evidence of temporary delay in usual sleep period sleep diaries for a period of at least two weeks.
LAG SYNDROME OF TIME ZONES (JET LAG)
Transient condition characterized by a series of biological, clinical and social regarding the rapid passage of time zones in intercontinental air travel. The fast travel long distances to the body undergoes a sharp mismatch between the physiological time, synchronous with the local time of the country of departure, and destination country time.
Clinically produces sleep disturbances (difficulty falling asleep and waking) and asthenia, as well as mood disorders, anxiety, decreased mental and physical performance and sometimes, digestive disorders. The severity of symptoms is proportional to the number of time zones crossed and the age of the individual. Also varies according to the direction of flight: traveling eastbound (which give rise to a sleep-wake rhythm advance) are more problematic than westward travel (delayed pace). Sleep efficiency decreases and the number of awakenings. Adapting to the local time zone requires 2-7 days depending on the length of travel and individual sensitivity. One problem is posed special interest riders (and other airline personnel) and executives who have to make these trips frequently.
The complaint of insomnia or excessive sleepiness. The symptoms began 1-2 days after air travel at least two time zones.
SHIFT WORK
The rotating work shifts have problems to adapt to a changing and circadian rhythm alterations increase with advancing age. Night workers or those who are subjected to frequent shift rotations generally show a marked deficit of sleep as daytime sleep is more fragmented and less restful than night, and this gives them with frequency, malaise, fatigue and irritability, an increased number of gastrointestinal and increased craving for alcohol, probably in order to attempt to control stress, and indiscriminate use of sedatives or hypnotics. There has been an increase in accidents and circulation in these workers. The symptoms occur especially the first days after the shift change. The situation can be worse if the worker does not follow a consistent pattern throughout the week and just keeps the cycle altered weekdays, returning to the normal cycle days off and vacations. The primary complaint is of insomnia or excessive sleepiness. The primary complaint is temporally associated with a work period (usually at night) that occurs during the normal sleep period.
ADVANCEMENT OF PHASE SYNDROME
It is much more exceptional than the phase delay. Is characterized by an irresistible sleep need, before the desired time, in the late hours of the evening, and waking up too early, at 2 or 3 am, with inability to return to sleep. The patient complains of unusually early hour they are awake. It occurs mainly in the elderly. Inability to stay awake until the desired time to sleep, or inability to remain asleep until the desired time of awakening. Symptoms are present for at least 3 months. Evidence of moving clocks forward in the usual sleep period by polysomnographic monitoring over a period of 24-36 hours. Not meet diagnostic criteria for any other sleep disorder causing inability to maintain sleep or excessive sleepiness.
The circadian rhythm of sleep and insomnia difference hypersomnia by history and by the fact that usually improves if the subject is allowed to follow their own sleep-wake rhythm.
Loa different circadian thymic disorders are:
1. Phase delay Sindromde
Two. Lag syndrome Time Zones (Jet Lag)
Three. Worker to turnso
April. Phase advance syndrome
May. Sleep-wake rhythm irregular
June. Hipernictameral Syndrome
PHASE SYNDROME SLEEP DELAY
The patient falls asleep and wakes up later than the desired time, in a period exceeding one month. It occurs mainly in adolescents and young adults, and 2 times more males than females. Many patients have chronic sleep deprivation due to the need to wake up in the morning to meet their social and labor obligations, and thus have daytime sleepiness. It can lead to a depressive syndrome. During holidays insomnia disappears because it can go its own sleep-wake rhythm without any problem. He complains of inability to fall asleep or wake up spontaneously at the desired time, or tiredness. Presents a delayed sleep phase with respect to principal desired sleep time. These symptoms must be present for at least 1 month.
When not require any strict sleep pattern (eg., On holiday), the patient:
1. It has a habitual sleep period that is deep and lasting quality and standard.
Two. He wakes up spontaneously.
Three. Maintains a stable pattern of sleep-wake 24 h, although with a lag phase.
April. Evidence of temporary delay in usual sleep period sleep diaries for a period of at least two weeks.
LAG SYNDROME OF TIME ZONES (JET LAG)
Transient condition characterized by a series of biological, clinical and social regarding the rapid passage of time zones in intercontinental air travel. The fast travel long distances to the body undergoes a sharp mismatch between the physiological time, synchronous with the local time of the country of departure, and destination country time.
Clinically produces sleep disturbances (difficulty falling asleep and waking) and asthenia, as well as mood disorders, anxiety, decreased mental and physical performance and sometimes, digestive disorders. The severity of symptoms is proportional to the number of time zones crossed and the age of the individual. Also varies according to the direction of flight: traveling eastbound (which give rise to a sleep-wake rhythm advance) are more problematic than westward travel (delayed pace). Sleep efficiency decreases and the number of awakenings. Adapting to the local time zone requires 2-7 days depending on the length of travel and individual sensitivity. One problem is posed special interest riders (and other airline personnel) and executives who have to make these trips frequently.
The complaint of insomnia or excessive sleepiness. The symptoms began 1-2 days after air travel at least two time zones.
SHIFT WORK
The rotating work shifts have problems to adapt to a changing and circadian rhythm alterations increase with advancing age. Night workers or those who are subjected to frequent shift rotations generally show a marked deficit of sleep as daytime sleep is more fragmented and less restful than night, and this gives them with frequency, malaise, fatigue and irritability, an increased number of gastrointestinal and increased craving for alcohol, probably in order to attempt to control stress, and indiscriminate use of sedatives or hypnotics. There has been an increase in accidents and circulation in these workers. The symptoms occur especially the first days after the shift change. The situation can be worse if the worker does not follow a consistent pattern throughout the week and just keeps the cycle altered weekdays, returning to the normal cycle days off and vacations. The primary complaint is of insomnia or excessive sleepiness. The primary complaint is temporally associated with a work period (usually at night) that occurs during the normal sleep period.
ADVANCEMENT OF PHASE SYNDROME
It is much more exceptional than the phase delay. Is characterized by an irresistible sleep need, before the desired time, in the late hours of the evening, and waking up too early, at 2 or 3 am, with inability to return to sleep. The patient complains of unusually early hour they are awake. It occurs mainly in the elderly. Inability to stay awake until the desired time to sleep, or inability to remain asleep until the desired time of awakening. Symptoms are present for at least 3 months. Evidence of moving clocks forward in the usual sleep period by polysomnographic monitoring over a period of 24-36 hours. Not meet diagnostic criteria for any other sleep disorder causing inability to maintain sleep or excessive sleepiness.
RATE IRREGULAR SLEEP-WAKE
Is a circadian rhythm sleep due to deregulation of internal biological clocks notified of the time (for example, time to wake up every morning), that evolves over a minimum period of three months, resulting in sleep fragmentation , both day and night, which is variable and irregular. This anomaly of the temporal distribution of sleep has an important relationship with daily routines, so it may be more common in people who lead a less structured life-students, unemployed, poor lifestyle (as common in young people schedules often have irregular sleep-wake), or bedridden, or lose those routines-old. If the total sleep duration is within normal limits for age, does not usually cause drowsiness. In individuals whose dream is broken into 3 episodes or more within 24 hours, there is insomnia and hypersomnia. The complaint of insomnia or excessive sleepiness. Presesna an irregular pattern of at least three episodes of sleep during a 24 hour period for at least three months. Tamper evident cronobiológico rate by any of the following:
1. Demonstration of loss of regular sleep-wake pattern by
Two. polysomnographic continuous monitoring for at least 24 hours.
HIPERNICTEMERAL SYNDROME
This condition produces a sleep-wake cycle than 24 hours, in 1-2 hours a day, so sleep periods are spaced every day and progressively settings get socially required. Periodically the dream recovers its normal night time, with improvement of the discomfort. This rhythm desynchronized sleep resembles that seen in individuals deprived of the main external synchronizers. This syndrome is especially common in the blind, in the event that it is not essential psychometric and psychiatric examination to rule out psychiatric disorders (mental deficiency, schizophrenia, severe drug addiction) and a neurological examination with radiological techniques to investigate the hypothalamic region, in order to rule out neurological tumor type or harmful. The main complaint of difficulty falling asleep or waking up. There is a progressive delay in the start and end of the dream, with inability to maintain stable sleep-wake pattern of 24 hours for at least 6 weeks.
TREATMENT OF CIRCADIAN RHYTHM DISORDERS
The therapeutic goal is to adjust the biological rhythm with standard time in which the individual lives. It is very difficult to overtake the biological clock to synchronize the sleep-wake rhythm, trying to get the patient to sleep before the time that you normally do, but with relative ease may be delayed. Used:
Chronotherapy: circadian rhythm disorder most prevalent sleep syndrome, delayed sleep phase, is characterized by difficulty falling asleep at times that society advises and difficulty getting up in the morning. When it allows patients with this disorder go to sleep and wake up when they want, usually his dream seems normal, except that the schedule is delayed. In chronotherapy set a reference time and is delayed bedtime gradually until it reaches the optimal time synchronization of the sleep-wake cycle.
Phototherapy light has been identified as the most potent stimulus to change the phase of human circadian rhythms. Workers who change shifts must maximize their exposure to sunlight while awake and minimize exposure during sleep. The artificial light radiation using special bulbs may reinforce internal rhythms adapt to the new change. Light therapy is a relatively new treatment, but effective for circadian rhythm disorders of sleep. Can be used in patients with delayed sleep phase and also in advance of those sleep phase (Table 2). The light management to wake up in the morning can advance circadian rhythms in patients with the syndrome of delayed sleep phase. Similarly, it has also been used to bright light exposure in the evening to treat patients with early evening sleepiness and early morning awakening. This form of therapy is a procedure that requires time and it has to be administered at a specific time of day. Consequently, monitoring can be a problem.
Jet lag can be prevented or treated with the administration of a hypnotic middle-short half-life. Normally suffice 1 or 2 doses.
Melatonin: It has demonstrated its involvement in regulating the sleep-wake cycle, improving the symptoms of jet-lag and phase lag syndrome. Its mechanism of action is unknown, but may relate to the interaction with melatonin receptors suprachiasmatic nucleus. Studies of hypnotic efficacy are inconclusive, and no data on the optimal dose, schedule of administration, indications, contraindications and toxicity. His prescription is not authorized in Spain, but has been introduced in the market in the United States and other Western countries.










